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Article
May 15, 1915

PRACTICAL PHARMACOLOGY

JAMA. 1915;LXIV(20):1655-1657. doi:10.1001/jama.1915.25710460001014
Abstract

XIX 

DRUGS WHICH ACT MAINLY ON THE HEART 

The Digitalis Group—(Continued) 

STANDARDIZATION  We have no satisfactory means of standardizing the digitalis bodies; there is no chemical test for determining the amounts of the various pure principles present, and none of the biologic tests is free from objection.The forthcoming Pharmacopeia will probably direct the standardization of digitalis bodies by means of the frog test, which consists in determining the amount required to cause the frog's heart to stop with the ventricle in systole in one hour. This test has the disadvantage of not affording a comparison of the therapeutic activities of such different members of the group as strophanthus and digitalis; for example, the amount of digitalis required to kill a frog of given weight by this method will have far greater therapeutic activity than the strophanthus required to kill a frog of the same size.Guinea-pigs are

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