Although no age is exempt from the incidence of diabetes, it is generally recognized that the disease runs a very rapid and almost invariably fatal course in young persons. The prognosis has usually been based, in the past, on a consideration of the period in life at which the symptoms first manifest themselves. During the youthful period a strict carbohydrate-free diet frequently fails to bring about a complete disappearance of sugar from the urine; and the ketonuria accompanying these severe types cannot always be made to disappear even when a liberal allowance of carbohydrate is permitted in the ration. The final characteristic death in coma is familiar to every practitioner.
Dr. E. Frank1 of Minkowski's clinic in Breslau has called attention to a relatively innocuous type of diabetic disease found in younger persons and designated as renal diabetes or, if one prefers to avoid the implication of the pathogenic
DIABETES WITHOUT HYPERGLYCEMIA. JAMA. 1915;LXIV(20):1661. doi:10.1001/jama.1915.02570460037019