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May 29, 1915


Author Affiliations


From the Otho S. A. Sprague Memorial Institute Laboratory of Clinical Research, Rush Medical College.

JAMA. 1915;LXIV(22):1811-1812. doi:10.1001/jama.1915.02570480007002

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A man aged 45 had an aneurysm of the thoracic aorta extending from the diaphragm upward. The diagnosis was based on the character and distribution of the pain, the existence of cardiac hypertrophy with a peculiarly metallic aortic closure, a history of lues, a positive Wassermann reaction in the blood, and a roentgenogram. No other explanation of the symptoms was found in spite of an exhaustive study.

This patient had been treated with iodids and mercury, and had at first improved, but later suffered excessively from pain. He had then been given salvarsan. Within eight days he received three doses of 0.3, 0.3 and 0.4 grams respectively of old salvarsan. Forty-eight hours after the last one he felt ill and had a temperature of 99 F. During the day this rose and at 8 p. m. it was 102. He then complained of headache and slight nausea. The bowels had

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