It is difficult to appreciate the fact that pernicious anemia is at present an incurable and fatal disease which in some respects is more to be dreaded than cancer. Its relapses, remissions, and merciless progressive course impress on us the necessity for a universal study of its manifestations. A thorough trial of splenectomy in the treatment of pernicious anemia is therefore warranted, though a consideration of the results is at present necessarily confused by fallacies and insufficient data. There is so far no evidence that splenectomy has cured pernicious anemia, but there are definite indications of consistent temporary improvement in a majority of instances.
Our early experience with splenectomy for pernicious anemia was discouraging. During the past two years, however, it has become evident that a marked reaction and a consistent temporary gain, at least for a period of months, follows splenectomy in selected cases, and surgical treatment has been
GIFFIN HZ. A REPORT ON THE TREATMENT OF PERNICIOUS ANEMIA BY TRANSFUSION AND SPLENECTOMY. JAMA. 1917;LXVIII(6):429–432. doi:10.1001/jama.1917.04270020109008