In an earlier paper1 before this section there were submitted arguments, based on experiments, tending to support the conclusion that all forms of serums and vaccines hitherto employed against gonorrhea were without definite dependable value, and apparent reasons for their failure were emphasized. Work of the past year tends to confirm these opinions and leads to further generalizations.
Starting from the fact that a true and lasting immunity against gonococcus infections is found in all animals and, as a rule, in all tissues of man, save only in certain special tissues, we pass on to observe that unqnably these receptive tissued in man are occasionally proof against infection, and appear to depend for their immunity, not so much on the presence of antibody, as on the existence of certain physical states within themselves and their fluids. But in the Present state of our knowledge we cannot hope to obtain
WARDEN CC. THE PHYSICOCHEMISTRY OF THE GONOCOCCUSIN RELATION TO IMMUNITY AND THERAPEUSIS. JAMA. 1917;LXVIII(6):432–438. doi:10.1001/jama.1917.04270020112009