During the last two years and a half an investigation of the basal metabolism in thyrotoxicosis has been carried out at the Massachusetts General Hospital. It was our original intention to report these data fully in a more technical paper first, and subsequently to discuss the clinical aspects of the work in a general paper. Since it now seems probable that we shall be unable to publish our work in detail until after the war, and since certain conclusions have been drawn which we believe will be of interest to clinicians, we are submitting at present an outline of our work, together with a discussion of the results obtained.
The manifestations of overactivity of the thyroid gland are numerous. Besides the well recognized features, such as tachycardia, nervousness, loss of weight, and tendency to increased sweating, a rise in the general heat production, or, as it is now commonly called,
MEANS JH, AUB JC. STUDY OF EXOPHTHALMIC GOITER FROM THE POINT OF VIEW OF THE BASAL METABOLISMWITH REMARKS CONCERNING THE EFFECT OF VARIOUS FORMS OF TREATMENT. JAMA. 1917;LXIX(1):33–37. doi:10.1001/jama.1917.02590280035012