Cancer of the prostate may be defined as a process of new growth or malignant degeneration of previous growths taking place primarily at any place within the capsule, or within that portion of the urethra which communicates directly with the glandular tissue of the prostate by way of its ducts.
For some reason, unknown and unexplainable with our present knowledge, that glandular group, lying between the submucosal urethral tissues and the posterior capsular surface, the so-called posterior lobe, is, or appears to be, the most frequent site for development of cancer of the prostate. It is claimed by Young and his school that the exceptions to this are very rare. We admit the value of this careful research work, but to us it seems that its conclusions are forced. It is often manifestly impossible to determine, when the disease is widely distributed, exactly which is the oldest part; but we
MacGOWAN G. CANCER OF THE PROSTATE. JAMA. 1917;LXVIII(7):521-526. doi:10.1001/jama.1917.04270020185007