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Article
February 17, 1917

DOES THE SPINAL FLUID FROM HUMAN POLIOMYELITIS CONTAIN THE SPECIFIC INFECTIVE AGENT?

Author Affiliations

NEW YORK

From the Bureau of Laboratories, Department of Health, City of New York.

JAMA. 1917;LXVIII(7):546. doi:10.1001/jama.1917.04270020210017
Abstract

Repeated attempts tto demonstrate the virus of poliomyelitis in the spinal fluid of human poliomyelitis both by cultures and by animal inoculation have all proved negative. Flexner and Lewis1 have demonstrated its presence in the spinal fluid from an infected monkey drawn three days after the time of the intracerebral injection of virus. This fact suggests that it may be present in the fluid at some stage of the incubation period. If it is present, it is prrobable that it diminishes rapidly with onset of the symptoms, but may not wholly disappear. It is possible that the virus is present in the later stages in such minute quantities that it cannot be demonstrated by animal inoculation.

Nuzum and Herzog2 have recently reported the finding of a gram-positive coccus in 90 per cent. of the spinal fluids from positive cases of acute poliomyelitis. This organism was isolated with apparent

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