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The opinion seems to prevail among those who have had no experience with "gas" anesthesia that it is useful only in minor surgery, for operations requiring only a brief anesthesia, and for operations of necessity on patients who cannot withstand tthe depression or acidosis produced by ehter or chloroform. Those who have done considerable operating under nitrous oxid-oxygen anesthesia know this opinion to be a fallacy. Almost any operation can be done under it, and it should unquestionably be the anesthesia of choice where there is the least possibility of the patient's chances of recovery being lessened by operative shock or postoperative depression or acidosis. Cases in which it has been used in major surgery for operations of from one and a half to three hours are by no means rare. A few cases of four hours' duration have been reported. But as far as my search of long a
McCurdy JR. LONG NITROUS OXID-OXYGEN ANESTHESIA: REPORT OF CASE. JAMA. 1917;LXVIII(7):547. doi:10.1001/jama.1917.04270020211018