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July 14, 1917


Author Affiliations


JAMA. 1917;LXIX(2):87-90. doi:10.1001/jama.1917.02590290009003

A pronounced bluish green, slate gray or dark brown permanent pigmentation of the skin is a very unfortunate accident that may follow the local therapeutic use of argyrol and the various other organic silver preparations.

The generalized argyria or argyria universalis following the internal use of silver nitrate, or occasionally its local application, has been well studied and recognized since the classical paper on this subject by Frommann1 in 1859.

The localized argyria or argyria localis following the local use of silver nitrate, and that occurring as an occupational argyria in workers in silver, is also well known, very valuable papers having been written on this subject by Blaschko2 and Lewin3 of Berlin in 1886, and more recently by Koelsch4 in 1912.

Comparatively little work has been done and very little has been published on the localized argyria due to the local use of argyrol and

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