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To the Editor:
—Dr. William G. Ward's letter (The Journal, Feb. 3, 1917, p. 390), and the recent admirable article by Dr. Harold N. Cole (The Journal, Dec. 30, 1916, p. 2012) recall to mind Dr. J. B. Murphy's clinical note on the use of sodium cacodylate in the treatment of syphilis (The Journal, Sept. 24, 1910, p. 1113), and the experimental work of Capt. H. J. Nichols, U. S. Army (The Journal, Feb. 18, 1911, p. 492). The results of Nichols' work conclusively proved, at least from a laboratory standpoint, that this drug was of very little value as a spirocheticide in combating syphilis. Prior to the publication of Dr. Murphy's letter, I had employed sodium cacodylate extensively as a remedy in psoriasis, and I still continue to use it in selected cases of the disease.Adopting Dr. Murphy's suggestion, I gave the agent an extensive trial in syphilis
Sutton RL. Sodium Cacodylate in the Treatment of Syphilis. JAMA. 1917;LXVIII(7):566. doi:10.1001/jama.1917.04270020230028