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July 28, 1917

THE PRODUCTION OF AN ANTIPOLIOMYELITIS SERUM IN HORSESBY INOCULATIONS OF THE PLEOMORPHIC STREPTOCOCCUS FROM POLIOMYELITIS

Author Affiliations

ROCHESTER, MINN.

From the Mayo Foundation.

JAMA. 1917;LXIX(4):261-266. doi:10.1001/jama.1917.02590310013004
Abstract

It is a well established fact that the serum of patients and monkeys which have recovered from poliomyelitis has a neutralizing1 and protective power2 against the virus of poliomyelitis. Inoculations of virus as well as of cultures of the globoid organism3 which fail to produce at least abortive attacks of poliomyelitis fail also to produce neutralizing and protective substances in the serum; hence immunity does not result. The recent work of Amoss4 proves further that the globoid organisms of Flexner and Noguchi5 have indeed little antigenic power. The need of immunization experiments along other lines in this disease is therefore apparent.

A restudy of the bacteriology of poliomyelitis during the past epidemic has emphasized anew the possible rôle which bacteria of ordinary size may play in the etiology of this disease. A pleomorphic streptococcus or micrococcus having elective affinity for the central nervous system in

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