For several years, as a matter of routine, I have been employing adrenalin chlorid in conjunction with cocain in many operations on the eye. At first this was done solely to lessen hemorrhage, but for some time I have used it not only for this purpose but because it soon became evident that through its action the anesthetic effect of the cocain was definitely increased.
In operations on the cornea and conjunctiva the anesthesia produced by cocain is, as a rule, so complete as to leave little to be desired, but this can not be said of certain other operations, notably those on the ocular muscles, on the lacrimal apparatus, and those done for the cure of chalazion or other tarsal cysts. Here, where much is to be desired in the direction of more perfect anesthesia, adrenalin has proved of undoubted value.
That adrenalin used in conjunction with cocain facilitates,
THEOBALD S. INDICATIONS FOR THE EMPLOYMENT OF ADRENALIN CHLORID, IN CONJUNCTION WITH COCAIN, IN OPERATIONS ON THE EYE.. JAMA. 1907;XLIX(4):326-327. doi:10.1001/jama.1907.25320040038002j