July 27, 1907


JAMA. 1907;XLIX(4):331-332. doi:10.1001/jama.1907.02530040043006

It sometimes happens that in a person who has already been vaccinated successfully against smallpox revaccination will give rise to definite reactions within twenty-four hours. This observation led von Pirquet1 to look for a similar precocious reaction in other infectious diseases. He has found that if tuberculin is introduced into the skin of a tuberculous child there will appear at the point of inoculation a small papule not unlike the papule of vaccination, at first bright, later more dark red, and lasting about eight days. A small quantity, about two drops, of diluted tuberculin (old) is placed on the skin and a small scarification is made with a sterile lancet right through the drop. Von Pirquet has made 500 tests and obtained a positive reaction in nearly all the cases of clinical tuberculosis in infants. It was not absent in any case of miliary tuberculosis, or of tuberculous meningitis

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