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Article
September 22, 1917

INFLUENCE OF LARGE DOSES OF DIGITALIS AND DIGITOXIN ON THE BLOOD PRESSURES IN MAN

Author Affiliations

NEW YORK

From the Department of Pharmacology, Cornell Medical College, New York.

JAMA. 1917;LXIX(12):951-955. doi:10.1001/jama.1917.02590390001001
Abstract

The influence of the several digitalis bodies on the blood pressure in both man and animals has been the subject of considerable study. It is now quite generally agreed that strophanthus, amorphous strophanthin and ouabain do not exert any direct vasoconstrictor action when administered to man in therapeutic doses, and the present tendency is to regard both digitalis and digitoxin as similarly devoid of such action. There is, however, still some divergence of opinion in regard to the latter drugs, and it is my purpose to review the essential literature relating to this question and also to present the results of a careful study of a small group of cases.

Gottlieb and Magnus1 reviewed the literature in support of the view that digitalis increased the blood pressure, and recorded a series of animal experiments which has done more, perhaps, than any other study to lead to the belief that

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