During recent years much experimentation has been carried out in determining the value of complement-fixation reactions for the diagnosis of tuberculosis.
Results obtained by different workers show considerable variation. When, however, it is remembered that the value of the test is entirely dependent on the specific action of the antigen and that the antigens used by the many investigators have been prepared by widely divergent methods, it is to be expected that the results should be somewhat dissimilar. At best, we are but feeling our way toward a common understanding of the relation which our laboratory findings bear to the disease itself, and the test will eventually be established as of practical value only by a thorough comparison of all careful investigations rather than by the consideration of the work of any one person.
Several experimenters have obtained results of much promise, but on account of cross fixations with syphilitic
BURNS NB, SLACK FH, CASTLEMAN P, BAILEY K. APPLICATION OF THE COMPLEMENT-FIXATION TEST TO TUBERCULOSIS. JAMA. 1917;LXVIII(19):1386-1389. doi:10.1001/jama.1917.04270050088002