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August 17, 1907


JAMA. 1907;XLIX(7):602-603. doi:10.1001/jama.1907.02530070072007

In this country tetanus antitoxin has given such successful results in preventing the development of tetanus after Fourth of July injuries that it has acquired the reputation of being almost a positive preventive of tetanus. There are too many possible sources of failure in the application of any therapeutic measure to expect invariable success, and hence it is to be expected that occasional instances will be reported in which antitoxin prophylaxis of tetanus has failed, even as it sometimes fails in diphtheria. A fairly careful scrutiny of the American literature for the past five years has not brought to light a single report of the development of tetanus in a person who had received a timely prophylactic dose of tetanus antitoxin. In European literature, however, a considerable number of such cases are now recorded, and on account of their bearing on the real value of prophylactic injections of tetanus antitoxin

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