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October 20, 1917


JAMA. 1917;LXIX(16):1352-1353. doi:10.1001/jama.1917.02590430046016

The phenomena of anaphylaxis have begun to play a prominent part in various departments of medicine. The anaphylactic nature of so-called serum sickness is now generally recognized, as it occurs as a direct consequence of the injection of a foreign protein into a human being. The analogy between asthma and anaphylaxis has been clearly set forth by Meltzer,3 among others, who points out that in both conditions the symptoms consist in a tonic stenosis of the small bronchioles of peripheral origin. The connection of hay-fever with anaphylaxis is one of great likelihood, and current investigation is being guided in the direction of such probability. Zinsser4 has remarked that there are a number of other clinical conditions which are less obviously anaphylactic in nature, but in which we have many good reasons for attributing an important part of the etiology to a state of hypersusceptibility. Thus the peculiar so-called

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