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Having noticed the frequency with which spirochetal infections are attracted to the lymphatic tissue, for example Spirochæta pallida to lymph glands, Spirochæta obermeieri to the spleen, and knowing the frequency with which spirillar forms are present in the mouth and familiar with the frequent history of enlarged tonsils preceding Hodgkin's disease, I was tempted to apply the specific stains for spirochetes to the glands in Hodgkin's disease.
This seemed the more likely to give results by coupling the observation of the peculiar giant cell formation described by Reed and by Longcope in the glands of Hodgkin's disease with the observation of Benda that the giant cell formation in syphilitic children's livers was made up of pale spirochetes.
With these thoughts in mind, I sent to a number of laboratories a request for glands of Hodgkin's disease which had been hardened in formalin. Dr. W. G. MacCallam, of Johns Hopkins, Baltimore,
WHITE WC. SPIROCHETES IN HODGKIN'S DISEASE.PRELIMINARY COMMUNICATION.. JAMA. 1907;XLIX(9):774-775. doi:10.1001/jama.1907.25320090050002