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August 31, 1907


JAMA. 1907;XLIX(9):777-778. doi:10.1001/jama.1907.02530090053005

The influence of morphin on the motor function of the gastrointestinal tract has long been a disputed point. In the human subject, the effect of morphin is usually seen in constipation, although in the non-habituated, as well as in the dog, the cat and the rabbit, diarrhea may be provoked. According to Nothnagel, this result is brought about by the action of the drug on a spinal center, small doses stimulating the inhibitory mechanism and large doses paralyzing it. Other writers contend that the morphin acts directly on the intestinal wall, while still others believe that the action is partly central and partly peripheral. Several observers have investigated the influence of morphin on the action of the stomach. Batelli reports that the gastric movements are at first stimulated and later inhibited. Hirsch, who studied the gastric movements of a dog through a duodenal fistula, states that the evacuation of the

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