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Article
September 28, 1907

SYSTEMIC BLASTOMYCOSIS AND COCCIDIOIDAL GRANULOMA.

JAMA. 1907;XLIX(13):1071-1077. doi:10.1001/jama.1907.25320130005001a
Abstract

INTRODUCTION.  Since the description by Gilchrist in 1894 of blastomycetic dermatitis numerous instances of this infection have been recorded by American observers. The clinical course, the characteristic double-contoured, budding organisms, and the distinctive gross and microscopic anatomy—especially the marked epithelial hyperplasia, the minute epidermal abscesses, and the peculiar granulomatous infiltration of the corium—early established the entity of blastomycetic dermatitis so firmly that denial of its existence, especially by certain German writers, never has received serious notice. H. G. Wells discovered the first case in Chicago, and the large number of cases observed in this city, especially by Professor Hyde and his associates, is noteworthy. Whether this apparent relative frequency of the disease here is in any way due to accidental conditions or to our being in the midst of an especially heavily infested territory remains to be seen.The interest in blastomycetic infection enlarged when it became known that this

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