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October 5, 1907


JAMA. 1907;XLIX(14):1188. doi:10.1001/jama.1907.02530140034004

In 1903 it was reported by Josué that rabbits which had received several injections of adrenalin developed, as a result, marked arteriosclerosis of the large vessels and aorta. This announcement was of great importance, both for the practicing physician and the experimental pathologist—to the former it suggested the possibility of harmful results from too extensive use of adrenalin therapeutically, and to the latter it furnished a means for experimentally producing a form of arteriosclerosis which might facilitate the study of the pathogenesis of this condition. Consequently, the subject was at once taken up on all sides, and a remarkably large number of papers d scussing this effect of adrenalin has appeared in the last three years. The general conclusions of all these reports have been as follows: Josué's main contention has received complete confirmation, for it has been found that a considerable proportion of all rabbits receiving injections of adrenalin

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