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February 10, 1894


JAMA. 1894;XXII(6):194-195. doi:10.1001/jama.1894.02420850022004

Some recent clinical applications of guaiacol invite a consideration of its chemic and therapeutic relations. "Guaiacol is a substance that occurs in wood-tar,and is also produced by heating pyrocatechin and potassium methyl-sulphate to 180 degrees, C. It is a colorless liquid that boils at 200 degrees, C., and has a specific gravity of 1117. It is readily soluble in alcohol, ether, and acetic acid, and is recommended instead of creasote in pulmonary tuberculosis."1 This substance is a prominent constituent of the best creasote, into which it enters to the extent of about 60 per cent., although in the cheaper kinds it may be much less than this. Along with the guaiacol, are associated a number of more or less objectionable substances. Among these, according to Allen, are phenol, paracresol, cresol, kylenol, creasol, homocreasol, cœrneignol, and four methylic ethers of trihydric phenols. Many of the foregoing are distinctly toxic, but

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