While a slight amount of eversion of the female urethra is not uncommon, a pronounced bulging or prolapse of the mucous and submucous tissues is fortunately rare. The condition is found with greatest frequency in children, namely, in 60 per cent, of reported cases, while in patients aged from 15 to 40, only 12 per cent, are noted. Again, the percentage rises to 28 per cent. in women affected who are over 40 years of age. The youngest patient mentioned was an infant 5 days old, and the oldest was a woman of 92 years. Debilitated children and old people are those most often affected.
Portions of the mucous membrane removed have been carefully studied by various observers, and in some instances the tissues were found normal, while other specimens examined showed evidences of vascular and inflammatory changes. A number of investigators reported angiomatous nodules with vascular and connective tissue
KEEFE. JW. PROLAPSE OF THE FEMALE URETHRA. JAMA. 1917;LXIX(23):1935-1938. doi:10.1001/jama.1917.02590500017004