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December 8, 1917


JAMA. 1917;LXIX(23):1952-1954. doi:10.1001/jama.1917.02590500034008

During the past ten years, my assistants and I have experimented with many various substances in the hope of throwing some light on a better understanding of the cancer problem.

The work1 first reported contained a brief case report on the use of vaccines prepared from cancer protein, and later publications2 gave reports of various scientific findings as they were encountered during the progress of this study.

Other workers, notably Blumenthal3 and Lünchenbein,4 have reported clinical observations which corresponded to those that I had previously reported. From a scientific standpoint, the work of Gruner5 agrees with changes I have observed chiefly in advanced malignancy, while of decided corroborative value is the research of Murphy,6 showing the effect of spleen destruction on the transplantability of tumors.

Indeed, the literature on the subject of malignancy abounds with isolated observations made by many independent investigators which, when

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