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December 15, 1917


JAMA. 1917;LXIX(24):2042-2043. doi:10.1001/jama.1917.02590510034016

The normal response of the organism to a loss of red blood corpuscles, such as occurs through hemorrhage, consists in an increased activity of the blood-forming cells of the red bone marrow. New erythrocytes are formed to replace those of which the circulation has been deprived. This corrective mechanism, if it may so be termed, is the wholesome device whereby a harmful diminution in oxygen-carrying capacity of blood is prevented and the necessary factors for proper tissue respiration are restored. Heretofore it has not always been easy to follow the course of a regeneration of red corpuscles or to investigate the process at the seat of their formation, for, as Starling6 has expressed it, in the confused medley of colorless cells which exist in the bone marrow and are precursors of all the varied corpuscles found in the blood, it is difficult to be certain of the identity of

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