Of the treatment of general paresis, Ogilvie1 has said:
The real problem is to recognize invasion of the central nervous system before even the interstitial tissue or the meninges are involved to any destructive extent. It is the consistent opinion of authorities generally that these parts are invaded prior to this period. If neurologic involvement is detected at this stage, we have adequate means of controlling it, and if these are judiciously employed, general paresis will, in not far distant years, become a comparatively rare picture in medicine.
We may add, not only general paresis but any form of cerebrospinal involvement.
There is no form of the later manifestations of syphilis so heartrending to the patient and his family and so discouraging to the clinician as the involvement of the cerebrospinal system. Occurring most frequently many years after the primary infection, this class of cases presents a pitiful picture,
CORBUS BC. PROPHYLAXIS IN CEREBROSPINAL SYPHILIS. JAMA. 1917;LXIX(25):2087-2089. doi:10.1001/jama.1917.02590520009004