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This monograph opens with a concise discussion of the physical and chemical principles which determine the solution and precipitation of those substances which form urinary and biliary calculi. There then follows a discussion of the same principles as applied to the special cases of urinary and biliary calculi. Particular emphasis is laid on the importance of the colloid substances which form the framework of the calculi, and which are maintained to be fundamentally active in both their origin and growth. The colloids presumably concentrate on the surface of any nucleus present, until they form a veritable membrane, which becomes saturated with salts; this new layer provides another surface on which colloid concentration occurs, and so the calculus is formed of laminae. As the title indicates, only the formation of calculi is discussed: their results and treatment are not considered. There are excellent illustrations, and the monograph constitutes an important contribution
Ueber die Bildung der Harn- und Gallensteine.. JAMA. 1915;LXV(2):193. doi:10.1001/jama.1915.02580020059035