There is a close conformation of the brain to the size and shape of the skull, and for this reason measurements of the craniums of living subjects must become of increasing importance. Studies directed to the changing brain mass by means of craniometry appeal especially to students of diseases of children because developments of physiologic and pathologic significance that may be detected by this method are very generally completed before the adult stage is reached. Of the normal factors that modify the shape of the skull, aside from variants, heredity, mental training and character development are the most important, while the abnormal factors are typically illustrated in children afflicted with rickets, syphilis and acromegaly.
It is readily admitted that the many conditions that control skull shapes render it difficult, with our present knowledge, to make positive statements relative to the value of craniometry as a diagnostic agent. It would seem,
CLARK GH. CRANIOMETRY IN DISEASES OF CHILDREN. JAMA. 1915;LXV(5):405-407. doi:10.1001/jama.1915.02580050033009