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May 9, 1903


JAMA. 1903;XL(19):1296. doi:10.1001/jama.1903.02490190026011

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As was told in The Journal last week, in our special telegraphic report from Boston, the etiology of smallpox is now known through the work of Drs. W. T. Councilman, Geo. B. McGrath and W. R. Brinckenhoff. It is a sporozoon first suggested by Guarnieri as the cause of variola and named by him Cytoryctes vacciniœ. On Monday evening, at another large meeting of medical men, at the Boston Medical Library (soon to be the Academy of Medicine), Dr. E. E. Tyzzer described his elaborate work on the organism of vaccinia, performed during the spring and summer of last year. Experiments were made by inoculating rabbits' corneas with vaccine virus and with the contents of the pustules of variola. Microphotographs showed every stage of the asexual cycle of Cytoryctes vacciniœ in the cases in which virus was inoculated, the sporozoa appearing in sixteen hours in the epithelial cells, and every

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