Attention has again been called to the inaccuracy which characterizes much of the thyroid medication. In a recent publication, Beebe1 discusses especially the wide variations in the iodin content of the thyroid most frequently used for medicinal purposes (that of the sheep), and advocates the use of an extract containing a standard amount of iodin.
There can be little doubt that the therapeutic efficiency of thyroid is largely determined by the iodin content, although, as Hunt and Seidell2 pointed out three years ago, the clinical evidence for this, while very convincing so far as it goes, is not extensive. These authors found that the iodin content of most of the commercial dry thyroids on the American market ranged between 0.1 and 0.2 per cent, and suggested that it would perhaps be desirable to fix a standard of not less than 0.12 per cent. iodin for the official preparation.
INACCURACY IN THYROID MEDICATION. JAMA. 1911;LVI(23):1724. doi:10.1001/jama.1911.02560230026016