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Article
June 10, 1911

SOME CONSIDERATIONS REGARDING THE USE OF DIPHTHERIA ANTITOXIN

JAMA. 1911;LVI(23):1725-1726. doi:10.1001/jama.1911.02560230027018
Abstract

There is no difference of opinion among unprejudiced observers as to the great life-saving value of diphtheria antitoxin. Carefully prepared and impartially analyzed statistics show that the average mortality from the disease prior to the introduction of the antitoxin as a therapeutic measure has been reduced one-half or more under the employment of this agent. In addition, the duration of the individual attack is shortened and its severity lessened. Among other things, unpleasant sequels, such as the paralysis resulting from peripheral neuritis, have become less frequent. Moreover, through the employment of prophylactic injections the spread of the disease has been checked and in numerous instances local epidemics have by the same means been brought to an end.

It was recognized even early in the history of the treatment that the procedure was not unattended with possibilities of danger. Perhaps the first death in the sequence of an injection of diphtheria

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