November 27, 1915


JAMA. 1915;LXV(22):1919-1920. doi:10.1001/jama.1915.02580220059025

The time relations of metabolism are beginning to arouse the attention of investigators. This is the result of the advance in knowledge of the biologic performances of the organism. In earlier days it represented progress to be able to contrast the beginning and the end results of metabolism; to measure accurately the intake and output of matter and energy, and to account exactly for the expenditures of the organism. This no longer suffices for the properly inquisitive physiologist. He is determined on learning where and how the intermediate stages of nutrition are carried on, so that each step in the fundamental chemical changes in the living body can be followed. The pathology of nutrition has thus gained a broader outlook. In the future, defects of function are to be located more specifically. It will no longer suffice to say that sugar is not burned up in some individual organism, and

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