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This small book is an authoritative statement of the work leading to the introduction of salvarsan. The largest part of it is by Hata on the experimental basis of the chemotherapy of spirilla. There is a brief report of the action of salvarsan on the Spirochœta pertenuis in the animal body by Nichols, one on patients with relapsing fever treated with the drug in the Cairo Infectious Hospital by Bitter and Dreyer, and the work concludes with a fairly comprehensive survey of the general subject by Ehrlich. It goes without saying that it is a highly interesting narrative. Hata's statement in particular of the preliminary chemical work and of the principles followed in it holds one as an account of one of the most original investigations of modern therapeutic chemistry. Ehrlich in his "concluding remarks" traverses in part the same ground and shows the steps by which he gradually came
The Experimental Chemotherapy of Spirilloses (Syphilis, Relapsing Fever, Spirillosis of Fowls, Frambesia).. JAMA. 1911;LVII(6):500. doi:10.1001/jama.1911.04260080064030