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Article
November 9, 1907

SECONDARY TUMORS OF BONES.

JAMA. 1907;XLIX(19):1608-1609. doi:10.1001/jama.1907.02530190042005
Abstract

By making more frequent and more thorough examination of the bony skeleton a part of the routine of autopsies, pathologists have learned recently several interesting facts concerning the development of secondary tumors of the bones that should be appreciated by clinicians. In the first place it has been found that metastatic growths in the bone occur much more frequently than has been generally supposed; E. Fraenkel1 discovered metastasis in the bones in 20 per cent, of all cases of carcinoma coming to autopsy, and Fischer-Defoy2 found bone involvement in 25.7 per cent. Had the entire osseous system been examined instead of merely the vertebral column and an occasional long bone, it is probable that these figures would have been considerably raised. Secondary carcinomas as found in the bones at autopsy are usually not conspicuous structures, and will generally escape observation unless sought for with care. In a large proportion

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