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My clinical experience with the intravenous injection of mercury in syphilis is as yet limited. I nevertheless feel warranted in presenting that experience to the profession. I confess that it was with some hesitancy that I adopted the method. I have, however, been pleased with my experience thus far. I herewith submit a report of ten cases in which I have used the intravenous injection with mercuric chlorid. It will be understood that I do not claim that the intravenous method was the only one available in all these cases, nor am I yet in a position to assert that it should be used as a routine practice. In several, however, it was a most valuable therapeutic resource, and in all of them its action was superior to that of any other method in my experience. In "malignant" cases and lesions that seriously menace the integrity of the nervous system
LYDSTON GF. INTRAVENOUS TREATMENT OF SYPHILIS.. JAMA. 1907;XLIX(20):1662-1663. doi:10.1001/jama.1907.25320200020002d