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In the present state of knowledge fever must be looked on as a symptom-complex resulting from some derangement of the bodily chemistry, from some disturbance in metabolic equilibrium, which may be brought about in a variety of ways. The causative factors may be generated within the body, or they may be introduced from without, in either event operating through the agency of the nervous system. Thus, fever may result from the retention within the body of the excrementitious products of retrogressive metamorphosis, as in cases of uremia; in consequence of profound changes in the blood, as in cases of anemia; from exposure to intense heat, as in cases of insolation; and it occurs readily in children—in whom the nervous system is notoriously unstable—on slight provocation, such as gastrointestinal derangement and even emotional influences. Most commonly, however, fever is due to changes secondary to infective processes—in other words, to the
ESHNER AA. THE MANAGEMENT OF FEVER IN GENERAL.. JAMA. 1903;XLI(2):101-102. doi:10.1001/jama.1903.04470040029010