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Article
November 23, 1907

THE DURATION OF THE ACTION OF ADRENALIN.

JAMA. 1907;XLIX(21):1779. doi:10.1001/jama.1907.02530210051010
Abstract

The prompt action of adrenalin in raising the systemic blood pressure has been of great service in such conditions as shock in which the tone of the arterial system has been temporarily depressed. The duration of its action, however, is comparatively short, and to obtain any sustained results it is necessary to repeat the dose frequently. As the result of experiments, Kretschmer1 reports that the action of adrenalin continues so long as there is any adrenalin in the blood, but that it is very shortly destroyed through the action of the alkalies of the blood and tissues. By the intravenous injection of mineral acids in experimental animals he was able to delay this destruction and thus to prolong the action of the drug to five or six times its usual duration. Just what effect the injection of the acid produces on the animal is not stated, but if it

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