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The removal of epitheliomaby the knife or caustic has so far, been seldom, if ever a permanent cure, and as this disease appears mostly on the face especially near the eyes or mouth and in persons advancing in years, it becomes a source of distress and pain as well as a blemish, and in the removal by knife or caustic often a very defective scar is left with contractions of the lids and mouth which interfere with the natural and proper use of those parts. Transplanting from neighboring parts creates a greater defect, really defacing two parts; that where the epithelioma was, and that from which the piece of skin transplanted was taken. The drawing of the edges of the wound together where the disease is cut out causes very much contraction, interfering with the opening of the eyes or mouth. Even after such an operation, return of the disease
KEYSER PD. GRAFTING FOR THE CURE OF EPITHELIOMA.. JAMA. 1894;XXIII(9):353. doi:10.1001/jama.1894.02421140027002g