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Article
November 18, 1911

THE VALUE OF THE WASSERMANN REACTION AND OF SALVARSAN

JAMA. 1911;LVII(21):1659-1661. doi:10.1001/jama.1911.04260110159003
Abstract

I. THE VALUE OF THE WASSERMANN REACTION, BY A. KEIDEL  These observations are based on 378 cases examined by the Wassermann test at the Genito-Urinary Clinic of the Johns Hopkins Hospital. The technic of the test followed the original method of Wassermann, Neisser and Brück, except in the preparation of the antigen, which was made by the method devised by Noguchi from syphilitic livers and from normal beef hearts. The unit of volume was also reduced and a water bath used in place of the air incubator.Fifty of the cases examined were definitely nonsyphilitic, including cases of epithelioma, sarcoma, tuberculosis, Raynaud's disease, scabies, acne, drug-rashes, and about twenty other various affections. In every case the reaction was negative.There were sixty-four cases of undoubted syphilis with secondary manifestations at the time the test was made and of these 91.4 per cent, gave a positive reaction. Somewhat over half of

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