In the light of our present knowledge, the treatment of syphilis without the certain information to be gained by means of the Wassermann reaction is more or less uncertain, and the same may be said for the diagnosis in many of its obscure and protean manifestations, conditions which were up to the last few years the subject of therapeutic diagnosis and guesswork.
For the past two years we have treated and kept under observation a series of patients in the military service at Vancouver Barracks, Washington. The clinical work was performed separately from the laboratory work; in fact, the former was done by reasoner at Vancouver Barracks, and the latter by Matson at Portland, Oregon. In this manner it is believed that the personal element was largely eliminated.
In this series we have used various methods of treatment and followed closely over sixty cases of syphilis running all the way
MATSON RW, REASONER MA. THE INFLUENCE OF TREATMENT ON THE WASSERMANN REACTION IN SYPHILIS. JAMA. 1911;LVII(21):1670-1675. doi:10.1001/jama.1911.04260110170006