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December 21, 1907


Author Affiliations

Professor of Neuropathology and Associate Professor of Neurology in the University of Pennsylvania. PHILADELPHIA.

From the Department of Neurology and the Laboratory of Neuropathology in the University of Pennsylvania.

JAMA. 1907;XLIX(25):2059-2065. doi:10.1001/jama.1907.25320250011001b

Under the name of hemicraniose Brissaud and Lereboullet1 describe a condition observed by them in two cases—a hypertrophy localized exclusively to a half of the cranium including the face. The first patient had epileptic convulsions. The enlargement of the head was first noticed about the age of two months, and it was slowly progressive and without pain. The patient had no headache, although he complained of a sense of heaviness in the head. His vision was good. He had no vomiting. The interesting feature of the case was the frontoparietal exostosis. The prominence did not extend into the occipital region nor beyond the median line. There was also a supraorbital enlargement of bone, but the rest of the face was not affected. This was purely a clinical case.

The second patient, a woman, had cranial hemihypertrophy dating from childhood, also signs of brain tumor, the latter of two and a

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