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SATURDAY, DECEMBER 16, 1911
THE EDEMA OF NEPHRITIS
The appearance of edema is a symptom which of itself demands remedial measures. So long, however, as the genesis of the edematous condition is not more clearly understood we cannot expect to advance far beyond the limits of empirical treatment in any attempted relief. The uncertainty or essential difference of opinion involves the question as to whether the immediate cause of nephritic edemas is to be sought in the kidneys themselves or in some extrarenal factor. Is the inability of the kidneys to secrete water the fundamental feature, or their inability to secrete salts? Salt retention has frequently been regarded as the direct occasion for the attendant holding back of water to preserve an osmotic balance
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. JAMA. 1911;LVII(25):1998-2001. doi:10.1001/jama.1911.04260120188024