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Article
December 23, 1911

COMPLEMENT IN HUMAN SERUM

Author Affiliations

Resident Pathologist, St. Luke's Hospital NEW YORK

From the Pathologic Laboratory, St. Luke's Hospital, New York.

JAMA. 1911;LVII(26):2063-2064. doi:10.1001/jama.1911.04260120253012
Abstract

C. C. Bass,1 in "A New Conception of Immunity," draws interesting conclusions from several statements, the experimental proof of which he unfortunately does not give. The broad application made of the principles stated, and the fact that, as stated, they are contrary to generally accepted ideas, encouraged the following brief experiments.

The statements referred to are as follows:

"Human complement capable of acting with human amboceptor to produce lysis... is destroyed by any temperature above normal body temperature.... A temperature of 40 C. (104 F.) destroys complement in human serum in from fifteen to thirty minutes and prevents lysis regardless of the amount of amboceptor employed."

"Freshly drawn human blood contains little or no complement capable of acting with human amboceptors.... No human specific complement develops at ordinary fever heat, 38 to 40 C. (101-104 F.), such as obtains locally and often generally in most inflammations."

"In the event

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