The exophthalmic syndrome is now generally conceded to be due to excessive secretion of the thyroid gland, and as a result of this view recent therapeutic measures have been directed toward removal of a portion of the secreting tissue. In connection with this I desire to express my suspicion that too much emphasis has been placed on a merely excessive secretion. The histopathology of the exophthalmic thyroid should make us suspect that the secretion is not only excessive, but also is changed in character, for the reason that whenever gland-cells depart from the usual as markedly as is indicated by tinctorial chemistry in these glands, there is likely to be some change in their product. I desire to question emphatically the entire correctness of the minor premise before beginning my argument.
From time to time inquiries as to the relation of the thyroid to other organs have been conducted. It
HERTZLER AE. THE RELATION OF PELVIC DISEASE TO EXOPHTHALMIC GOITER. JAMA. 1911;LVII(26):2076-2079. doi:10.1001/jama.1911.04260120266017