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December 28, 1907


JAMA. 1907;XLIX(26):2157. doi:10.1001/jama.1907.02530260029008

An interesting contribution to the study of the metabolism of fever is to be found in the work of Ott and Scott,1 which tends to disprove the theory of Krehl and his followers that the metabolic process in infectious fevers is of a different nature from that produced by stimulation of the thermogenic centers. While fever from either of these causes is accompanied by glycogen destruction, these observers have claimed that proteid catabolism is seen in the infectious fevers, but not in the fever of thermogenic origin. Puncture of the thermogenic center or the injection of proteoses or peptones into normal rabbits will cause a rise of temperature, but Rolly has shown that these procedures have no effect on glycogen-free rabbits, in which the injection of bacteria will produce fever. This he supposes to be due to the fact that fever of thermogenic origin is dependent on glycogen destruction

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