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SATURDAY, DECEMBER 23, 1911
THE ISLET THEORY OF DIABETES
It is now over ten years since the theory of the dependence of human diabetes on functional insufficiency of the islands of Langerhans was brought forward, but, attractive as the hypothesis is, there is not yet unanimity of opinion as to its validity. Even the fundamental matter of the independence, anatomically and functionally, of the islets has been doubted by some who have found reasons for believing that the islets may merely represent pancreatic tissue in certain stages of functional activity, development or regeneration. Pathologists also have observed that lesions of the islands of Langerhans might exist without the presence of glycosuria. In many cases of fatal diabetes no lesions of the islands could be found.
THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. JAMA. 1911;LVII(26):2086-2090. doi:10.1001/jama.1911.04260120276023