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There is so much of promise in the recent developments of serum therapy, especially in the brilliant success of the antitoxin treatment of diphtheria, that new interest has been aroused in the work of experimenters in this line with other diseases. The labors of Spronk of Paris, Coley of New York, Gehrman of Chicago and others in the treatment of the malignant tumors by the erysipelas toxins shares in this revival to an extent which warrants some review of the subject.
The theory of an antagonism between the products of growth of the streptococcus erysipelatosus and some forms of sarcomata and carcinomata is founded upon observations that these tumors occasionally disappear coincidentally with, or subsequent to, an attack of erysipelas in a distant part of the body. It was found that they had undergone tissue necrosis with absorption or extension; that lesions of lupus and of tertiary syphilis were similarly
ERYSIPELAS TOXINS IN THE TREATMENT OF MALIGNANT TUMORS.. JAMA. 1894;XXIII(17):650-651. doi:10.1001/jama.1894.02421220022005