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August 22, 1903

THE APPARENT IMMUNIZING VALUE OF ATTENUATED TUBERCLE BACILLI.

Author Affiliations

Director of Biochemic Laboratory, Bureau of Animal Industry, Department of Agriculture, and Dean, the Columbian Medical School. WASHINGTON, D. C.

JAMA. 1903;XLI(8):473-475. doi:10.1001/jama.1903.92490270001001
Abstract

The recent attention which has been drawn to the difference in virulence of tubercle bacilli from various animals, and the publication by Behring of the production of immunity to tuberculosis in cattle by the use of tubercle bacilli of low virulence, have suggested that if perhaps a little more attention had been given to some work published in December, 1894, there would have been less tendency in some quarters, at any rate, to assume an absolute difference between tubercle bacilli obtained from men and those obtained from cattle. The published works of the writer and Dorset and Schroeder, Ravenel, Nocard and that of others, have shownso conclusively that it is possible to obtain tubercle bacilli, sometimes from the sputum of adults and frequently from intestinal lesions in children, which will produce tuberculosis in cattle when the latter are inoculated subcutaneously, that

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