Following the excellent work of Crow in 1908, hexamethylenamin has come into quite general use, as can be seen by a review of the recent literature. Its elimination, dosage, action, etc., have been studied, but little if anything has been written regarding its toxic effects, if they have been observed.
In 1899, Nicolaier1 demonstrated that hexamethylenamin was excreted in the urine, and Sollman2 showed that a considerable part, if not all the drug excreted by the kidneys, was excreted unchanged, and broke down liberating formaldehyd only after remaining in the bladder for at least one and a half hours. It has, therefore, been recommended in genito-urinary infections, and as a prophylactic when catheterization has to be resorted to for any length of time.
Crow,3 in 1908, showed that when hexamethylenamin was given by mouth it was rapidly absorbed and remained in the circulating blood for twenty-four hours.
FULLERTON WD. HEXAMETHYLENAMINREPORT OF A CASE OF MEDICINAL CYSTITIS FOLLOWING ITS ADMINISTRATION. JAMA. 1912;LVIII(2):78–80. doi:10.1001/jama.1912.04260010080002